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المزارتان مدوکسومیل
6.2.5 Olmesartan Medoxomil: A Prodrug of Olmesartan Olmesartan is a durable, specific, and competitive nonpeptide angio- tensin II receptor antagonist used to treat hypertension.
To achieve better oral bioavailability its ester prodrug, olmesartan medoxomil, was developed.
Olmesartan medoxomil is suitable for once-daily oral administration and is available in tablet form (Bianca, 2007).
Case study: olmesartan medoxomil: a prodrug of olmesartan.
Reduced potential for abuse due to prolonged release of active drug Influenza Oseltamivir (Tamiflu) Ethyl ester of oseltamivir carboxylate Improved bioavailability compared with oseltamivir carboxylate, allowing oral administration Hypertension Olmesartan medoxomil (Benicar) Cyclic carbonate ester of olmesartan Improved bioavailability compared with olmesartan, allowing oral administration Immunosuppressant Mycophenolate mofetil (Cell Cept) Morpholinyl ethyl ester of mycophenolic acid Improved oral bioavailability with less variability Glaucoma Latanoprost (Xalatan) Isopropyl ester of latanoprost acid Bioconversion by esterases.
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